Severe heart indicators like rapidly, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
Bodily dependence is manifested by withdrawal symptoms right after abrupt discontinuation of the drug or on administration of the antagonist. Physical dependence and tolerance are not unusual through chronic opioid therapy.
In this example, blended agonist/antagonist analgesics might lessen the analgesic result of oxycodone hydrochloride tablets and/or may perhaps precipitate withdrawal indicators in these individuals.
Oxycodone hydrochloride tablets are contraindicated in sufferers with recognised hypersensitivity to oxycodone, or in almost any scenario exactly where opioids are contraindicated. This features sufferers with considerable respiratory despair (in unmonitored settings or perhaps the absence of resuscitative gear) and clients with acute or serious bronchial bronchial asthma or hypercarbia.
In the event you overlook a dose, skip the missed dose. Take your upcoming dose for the common time. Never double the dose to catch up.
Warning must be used in hypovolemic patients, which include Those people struggling acute myocardial infarction, due to the fact oxycodone could cause or further aggravate their hypotension. Warning should also be Employed in individuals with cor pulmonale who've been given therapeutic doses of opioids.
Abruptly stopping this medication may perhaps lead to withdrawal, especially if you've applied it for years or in higher doses. To forestall withdrawal, your health care provider check here may possibly lessen your dose slowly and gradually.
Respiratory depression can arise Anytime all through opioid therapy, specially when initiating and adhering to dosage improves with OXYCONTIN. Contemplate this risk when deciding on an initial dose and when generating dose changes [see WARNINGS read more AND PRECAUTIONS].
Dispose of expired, unwanted, or unused OXYCONTIN by instantly flushing down the bathroom, if a drug just take-back again alternative just isn't readily available. Go to for additional info on disposal of unused check here medicines.
The next adverse experiences happened in a lot less than 3% of patients associated with medical trials with oxycodone:
Teach patients and caregivers on how to get more info recognize respiratory despair and emphasize the value of calling 911 or obtaining unexpected emergency professional medical enable at once inside the function of a known or suspected overdose [see WARNINGS AND Safety measures and OVERDOSE].
Utilization of higher starting off doses in people who're not opioid tolerant may lead to lethal respiratory depression [see WARNINGS AND Safeguards].
Oxycodone hydrochloride tablets, like all opioid analgesics, may induce critical hypotension in a person whose capability to take care of blood pressure has been compromised by a depleted blood check here quantity, or following concurrent administration with drugs such as phenothiazines or other brokers which compromise vasomotor tone.
Retail store at home temperature faraway from mild and dampness. Don't shop in the lavatory. Hold all medicines away from small children and pets. See also Warning area.